ROOTED IN SCIENCE

The research behind your daily practice.

Explore the studies behind our products. From the headline findings to the original research, take a closer look at the evidence. 98 unique studies, drawing on 635+ underlying studies


  1. CHOOSE A PRODUCT Start with a formula or an Essential.
  2. EXPLORE A BENEFIT See the findings that matter to you.
  3. READ THE RESEARCH Review the method, result and original study.

8HOURS FORMULAS

8HOURS ESSENTIALS


Key Benefits

38 studies referenced, including our own placebo-controlled trial, drawing on 100+ underlying studies.


Explore the evidence.

All benefits · 38 studies


OUR OWN CLINICAL STUDY

8HOURS Clinical Study Preprint

8hours Sleep & Recovery Improves Sleep Quality: Placebo-Controlled Trial

Gurney, SportRxiv, 2026 - preprint, not yet peer-reviewed

Randomized, double-blind, placebo-controlled crossover; 16 recreationally active adults; 2 capsules nightly for 14 days. Significantly better sleep quality than placebo (p = 0.011): faster sleep onset, fewer night awakenings, less restless sleep and less morning tiredness. No difference in 48-hour muscle recovery measures.

Disclosure: Product tested as sold (100 mg magnesium, 200 mg L-theanine, 50 mg apigenin, 250 mg myo-inositol, 400 mg tart cherry extract, 15 mg BioPerine). Product supplied by 8hours, which had no role in the study. The author is an unpaid scientific advisor to 8hours and a minority shareholder.

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L-Theanine

7 ingredient references across benefits

L-theanine improves sleep quality: meta-analysis

Bulman et al., Sleep Medicine Reviews, 2025
Systematic review + meta-analysis of 19 RCTs, 897 participants

Significant improvement in sleep onset latency, daytime dysfunction and overall sleep quality

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L-theanine 200 mg: sleep, stress and cognition in healthy adults

Hidese et al., Nutrients, 2019
Randomized, double-blind, placebo-controlled crossover; 30 adults; 200 mg/day for 4 weeks

Better sleep quality score (PSQI); shorter sleep latency and fewer sleep disturbances vs placebo; lower anxiety scores

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Magnesium Bisglycinate

11 ingredient references across benefits

Magnesium bisglycinate in adults with poor sleep

Schuster et al., Nature and Science of Sleep, 2025
Randomized, double-blind, placebo-controlled; 155 adults; 250 mg elemental magnesium (as bisglycinate) for 4 weeks

Significantly greater reduction in insomnia severity than placebo

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Magnesium for insomnia in older adults

Abbasi et al., J Res Med Sci, 2012
Randomized, double-blind, placebo-controlled; 46 older adults; 500 mg/day for 8 weeks

Improved insomnia severity, sleep time, sleep efficiency and sleep onset; melatonin up, cortisol down

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Apigenin

5 ingredient references across benefits

Chamomile and sleep quality: meta-analysis

Hieu et al., Phytotherapy Research, 2019
Systematic review + meta-analysis of 12 RCTs

Significant improvement in sleep quality vs control

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Chamomile extract improves sleep quality in older adults

Adib-Hajbaghery & Mousavi, Complement Ther Med, 2017
Randomized, single-blind, placebo-controlled; 60 older adults; chamomile extract twice daily for 28 days

Significantly better sleep quality (PSQI) than placebo

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Myo-Inositol

1 ingredient reference across benefits

Myo-inositol improves sleep quality

Mashayekh-Amiri et al., J Matern Fetal Neonatal Med, 2022
Randomized, double-blind, placebo-controlled; 56 pregnant women; 2 g/day for 10 weeks

Better overall sleep quality, sleep duration and sleep efficiency vs placebo

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Tart Cherry

10 ingredient references across benefits

Tart cherry raises melatonin and extends sleep

Howatson et al., Eur J Nutr, 2012
Randomized, double-blind, placebo-controlled crossover; 20 healthy adults; 7 days

Higher melatonin; significant increases in total sleep time (about +34 min) and sleep efficiency

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Tart cherry in adults with insomnia

Losso et al., Am J Therapeutics, 2018
Randomized, double-blind, placebo-controlled crossover pilot; adults 50+ with insomnia; 2 weeks; sleep-lab measured

Sleep time up by 84 minutes; improved sleep efficiency

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BioPerine

3 ingredient references across benefits

Piperine boosts absorption of co-ingested compounds

Shoba et al., Planta Medica, 1998
Human crossover study; 20 mg piperine taken with curcumin

Bioavailability increased by 2000%

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Piperine raises CoQ10 absorption

Badmaev et al., J Nutr Biochem, 2000
Double-blind, placebo-controlled; 5 mg BioPerine with CoQ10 for 21 days

About 30% higher blood levels

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Key Benefits

27 studies referenced, drawing on 255+ underlying studies.


Explore the evidence.

All benefits · 27 studies


Creatine

9 ingredient references across benefits

Creatine: ISSN position stand

Kreider et al., J Int Soc Sports Nutr, 2017
Expert position stand reviewing 200+ studies

Consistently improves high-intensity exercise performance and training adaptations; safe and well tolerated

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Creatine and strength: meta-analysis

Lanhers et al., Sports Medicine, 2017
Systematic review + meta-analysis of controlled trials

Significant gains in upper-body strength vs placebo

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Taurine

5 ingredient references across benefits

Taurine improves endurance performance: meta-analysis

Waldron et al., Sports Medicine, 2018
Meta-analysis; 1-6 g taurine, single dose or up to 2 weeks

Significant improvement in endurance performance (effect size 0.40)

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Taurine and running performance

Balshaw et al., Amino Acids, 2013
Double-blind, placebo-controlled crossover; trained runners; 1 g taurine before a 3 km time trial

1.7% faster 3 km time

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L-Carnitine

3 ingredient references across benefits

L-carnitine raises muscle carnitine and work output

Wall et al., Journal of Physiology, 2011
Randomized, double-blind, placebo-controlled; 14 men; 24 weeks

Muscle carnitine up 21%, work output up 11%, lower perceived exertion

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L-carnitine and recovery after exercise: review

Fielding et al., Nutrients, 2018
Review of human trials

L-carnitine reduced markers of muscle damage and soreness after exercise

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Electrolytes (hydration status)

5 ingredient references across benefits

Exercise and fluid replacement: ACSM position stand

Sawka et al. (American College of Sports Medicine), Med Sci Sports Exerc, 2007
Expert position stand

Dehydration beyond 2% body mass degrades aerobic performance; sodium in drinks helps retain fluid

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Dehydration impairs cognitive performance: meta-analysis

Wittbrodt & Millard-Stafford, Med Sci Sports Exerc, 2018
Meta-analysis of 33 studies, 413 participants

Dehydration significantly impaired attention, executive function and coordination, especially beyond 2% body-mass loss

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Electrolytes (sodium, potassium, magnesium)

2 ingredient references across benefits

Beverage hydration index: electrolytes vs water

Maughan et al., Am J Clin Nutr, 2016
Randomized crossover; 72 men; 13 drinks compared with water

Electrolyte (oral rehydration) solution retained significantly more fluid than water (hydration index 1.54)

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Sodium content and rehydration after exercise

Shirreffs et al., Med Sci Sports Exerc, 1996
Randomized crossover; 12 men dehydrated by exercise; low- vs high-sodium drinks

Higher-sodium drinks retained more fluid and restored fluid balance

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Magnesium

1 ingredient reference across benefits

Magnesium: less tiredness and fatigue

EFSA Panel (NDA), EFSA Journal, 2010
Regulatory scientific opinion (basis of the authorised EU/GB claims)

Magnesium contributes to reduced tiredness and fatigue, electrolyte balance, energy metabolism and normal muscle function

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Vitamin B5

1 ingredient reference across benefits

Vitamin B5: mental performance, energy and fatigue

EFSA Panel (NDA), EFSA Journal, 2009 and 2010
Regulatory scientific opinions (basis of the authorised EU/GB claims)

Cause-and-effect established for normal mental performance, energy-yielding metabolism and reduction of tiredness and fatigue

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Selenium

1 ingredient reference across benefits

Selenium supplementation and mood

Benton & Cook, Biological Psychiatry, 1991
Double-blind, placebo-controlled crossover; 50 adults; 100 mcg/day for 5 weeks

Improved mood and lower anxiety, strongest in people with low dietary selenium

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Key Benefits

7 studies referenced, drawing on 55+ underlying studies.


Explore the evidence.

All benefits · 7 studies


Magnesium Bisglycinate

3 ingredient references across benefits

Magnesium bisglycinate in adults with poor sleep

Schuster et al., Nature and Science of Sleep, 2025
Randomized, double-blind, placebo-controlled; 155 adults; 250 mg elemental magnesium (as bisglycinate) for 4 weeks

Significantly greater reduction in insomnia severity than placebo

Read the study (opens in a new tab)

Magnesium for insomnia in older adults

Abbasi et al., J Res Med Sci, 2012
Randomized, double-blind, placebo-controlled; 46 older adults; 500 mg/day for 8 weeks

Improved insomnia severity, sleep time, sleep efficiency and sleep onset; melatonin up, cortisol down

Read the study (opens in a new tab)

Recovery and muscle

2 ingredient references across benefits

Magnesium reduces muscle soreness after training

Reno et al., J Strength Cond Res, 2022
Double-blind, placebo-controlled; 350 mg/day for 10 days; eccentric bench press protocol

Significantly less muscle soreness at 24, 36 and 48 h; better perceived recovery

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Magnesium and muscle soreness: systematic review

Tarsitano et al., J Transl Med, 2024
Systematic review of trials in physically active people

Magnesium reduced muscle soreness, supported recovery and had a protective effect on muscle damage

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Heart and stress

2 ingredient references across benefits

Magnesium lowers blood pressure: meta-analysis

Zhang et al., Hypertension, 2016
Meta-analysis of 34 RCTs, 2,028 participants; median 368 mg/day for 3 months

Systolic -2.0 mmHg and diastolic -1.8 mmHg vs placebo

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Magnesium, stress and anxiety: systematic review

Boyle et al., Nutrients, 2017
Systematic review of 18 studies

Benefit on subjective anxiety in stress-prone groups

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Key Benefits

7 studies referenced, drawing on 225+ underlying studies.


Explore the evidence.

All benefits · 7 studies


Creatine Monohydrate

7 ingredient references across benefits

Creatine: ISSN position stand

Kreider et al., J Int Soc Sports Nutr, 2017
Expert position stand reviewing 200+ studies

Consistently improves high-intensity exercise performance and training adaptations; safe and well tolerated

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Creatine and strength: meta-analysis

Lanhers et al., Sports Medicine, 2017
Systematic review + meta-analysis of controlled trials

Significant gains in upper-body strength vs placebo

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Key Benefits

4 studies referenced.


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All benefits · 4 studies


Glycine (3 g before bed)

4 ingredient references across benefits

Glycine 3 g before bed: sleep-lab study

Yamadera et al., Sleep and Biological Rhythms, 2007
Placebo-controlled crossover with polysomnography; adults with unsatisfactory sleep; 3 g before bed

Fell asleep faster, reached deep sleep sooner, better sleep quality and efficiency; less daytime sleepiness

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Glycine before bed: next-morning feel

Inagawa et al., Sleep and Biological Rhythms, 2006
Randomized, double-blind, placebo-controlled crossover; adults with poor sleep; 3 g before bed

Less fatigue and more clear-headedness the next morning

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Key Benefits

6 studies referenced, drawing on 85+ underlying studies.


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All benefits · 6 studies


Vitamin D3

2 ingredient references across benefits

Vitamin D supplementation and sleep quality: meta-analysis

Abboud, Nutrients, 2022
Systematic review of 19 studies + meta-analysis of RCTs

Significantly better sleep quality vs placebo (PSQI -2.33 points)

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Low vitamin D and sleep disorders: meta-analysis

Gao et al., Nutrients, 2018
Meta-analysis of observational studies, 9,397 participants

Vitamin D deficiency linked to about 50% higher risk of sleep disorders

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Vitamin D3: immunity and muscle

2 ingredient references across benefits

Vitamin D prevents respiratory infections: meta-analysis

Martineau et al., BMJ, 2017
Individual-participant meta-analysis of 25 RCTs, 11,321 participants

Lower risk of acute respiratory infection; largest benefit in deficient people taking daily or weekly doses

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Vitamin D and muscle strength: meta-analysis

Beaudart et al., J Clin Endocrinol Metab, 2014
Meta-analysis of 30 RCTs, 5,615 participants

Small but significant improvement in muscle strength

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Vitamin K2 and D3 + K2: bone and heart

2 ingredient references across benefits

Vitamin K2 (MK-7) slows bone loss

Knapen et al., Osteoporosis International, 2013
Randomized, double-blind, placebo-controlled; 244 postmenopausal women; 180 mcg/day for 3 years

Significantly less age-related decline in bone mineral density and bone strength

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Vitamins D and K work together: review

van Ballegooijen et al., Int J Endocrinology, 2017
Narrative review of human and mechanistic studies

Combined D + K appears more effective for bone and cardiovascular health than either alone

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Key Benefits

10 studies referenced, drawing on 115+ underlying studies.


Explore the evidence.

All benefits · 10 studies


Omega-3 (DHA / EPA)

2 ingredient references across benefits

Omega-3 (DHA-rich) improves sleep in healthy adults

Patan et al., Nutrients, 2021
Randomized, double-blind, placebo-controlled; 84 adults; 26 weeks; wearable-measured sleep

Better sleep efficiency and shorter time to fall asleep vs placebo

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DHA and sleep in children (DOLAB)

Montgomery et al., Journal of Sleep Research, 2014
Randomized, placebo-controlled; 600 mg DHA/day for 16 weeks; wearable-measured subgroup

58 minutes more sleep and 7 fewer night wakings

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Memory and cognition

4 ingredient references across benefits

DHA improves memory and reaction time in young adults

Stonehouse et al., Am J Clin Nutr, 2013
Randomized, double-blind, placebo-controlled; 176 healthy adults; 1.16 g DHA/day for 6 months

Better memory and faster memory reaction times vs placebo

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DHA improves learning and memory with age (MIDAS)

Yurko-Mauro et al., Alzheimer's & Dementia, 2010
Randomized, double-blind, placebo-controlled; 485 older adults; 900 mg DHA/day for 24 weeks

Significantly better learning and memory scores

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Mood

1 ingredient reference across benefits

Omega-3 and mood: meta-analysis

Liao et al., Translational Psychiatry, 2019
Meta-analysis of 26 RCTs, 2,160 participants

Significant benefit on depressive symptoms, driven by EPA-dominant formulas

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Heart

3 ingredient references across benefits

Marine omega-3 and heart health: meta-analysis

Hu et al., J Am Heart Assoc, 2019
Meta-analysis of 13 RCTs, 127,477 participants

Significantly lower risk of heart attack and coronary heart disease death

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Omega-3 lowers triglycerides

Skulas-Ray et al. (American Heart Association), Circulation, 2019
Science advisory reviewing clinical trials; 4 g/day EPA+DHA

Triglycerides reduced by roughly 20-30% or more

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Key Benefits

10 studies referenced, drawing on 16+ underlying studies.


Explore the evidence.

All benefits · 10 studies


Zinc

4 ingredient references across benefits

Zinc improves sleep onset and efficiency

Saito et al., Mol Nutr Food Res, 2017
Randomized, double-blind, placebo-controlled; 120 healthy adults; 12 weeks; wearable-measured sleep

Fell asleep faster and slept more efficiently with zinc-rich food

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Zinc and sleep quality in shift-working nurses

Gholipour Baradari et al., Workplace Health & Safety, 2018
Randomized, double-blind, placebo-controlled; 54 ICU nurses; 1 month

Better overall sleep quality and shorter sleep latency vs placebo

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Testosterone and thyroid

4 ingredient references across benefits

Zinc: authorised testosterone and fertility claims

EFSA Panel (NDA), EFSA Journal, 2010
Regulatory scientific opinion (basis of the authorised EU/GB claims)

Zinc contributes to normal testosterone levels and normal fertility and reproduction

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Zinc status and testosterone

Prasad et al., Nutrition, 1996
Controlled zinc restriction and supplementation study in men

Low zinc lowered testosterone; supplementing marginally deficient older men raised it

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Immunity

1 ingredient reference across benefits

Absorption (bisglycinate form)

1 ingredient reference across benefits

Zinc bisglycinate is better absorbed

Gandia et al., Int J Vitam Nutr Res, 2007
Randomized crossover; 12 healthy adults; bisglycinate vs gluconate

43% higher bioavailability with bisglycinate

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Read the evidence in context.

Research on individual ingredients is not the same as research on a finished formula. Many trials used a different dose or form from the product, including tart cherry juice rather than extract and 2 g inositol. Check each against the label. These callouts are study summaries, not approved claim wording.

This page brings together published research on the individual ingredients we use, alongside clinical studies carried out on 8hours products, including preprints not yet peer-reviewed, which are clearly labelled as such. For ingredient studies, the doses, forms and populations studied may differ from our formulations. Food supplements are not intended to diagnose, treat, cure or prevent any disease, and should not replace a varied, balanced diet and a healthy lifestyle.