ESSENTIAL

Ultrapure Glycine

Pure glycine powder. Clinically shown to deepen slow-wave sleep and lower core body temperature. Mix into any evening drink.
Ships by Tue, Sep 22 Royal Mail Tracked · 2–4 Working Days
Dr Tom Gurney
“Glycine is one of the most underrated sleep compounds in the literature. The evidence for its effect on core body temperature and slow-wave sleep depth is both robust and mechanistically well understood. At 3g, it genuinely works.”
Dr Tom GurneyChief Science Officer

Glycine

Actives per Serving
  • Glycine — 3,000mg
Other Ingredients

None. Single ingredient. Clean label — no fillers, flow agents or additives.

Glycine — 3,000mg

→ Deepens slow-wave sleep. Lowers core body temperature for faster sleep onset. Improves next-day alertness. Non-habit forming and non-sedating.

Order Processing:

Orders placed after 10:00 PM or on weekends/holidays will be processed the next business day.

Dispatch:

Orders are typically shipped within 1 business day from the time you receive an order confirmation.

Estimated Delivery Times:

Netherlands & United Kingdom: 1–3 business days
European Union (EU): 2–6 business days
International (outside EU): 2–15 business days

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Benefits

Why glycine works.

Deepens slow-wave sleep

Increases time in slow-wave (deep) sleep - the most physically restorative stage. Consistently improved vs. placebo at the 3g dose across multiple RCTs.

Lowers core body temperature

Promotes peripheral vasodilation, moving heat from your core to your extremities. This drop in core body temperature is the trigger for faster, more natural sleep onset.

Sharpens morning alertness

Multiple RCTs show significant reductions in daytime sleepiness and cognitive fog the morning after. Glycine improves the night and the day that follows.

Non-habit forming

A naturally occurring amino acid your body already produces. No GABA receptor binding, no sedation, zero dependency risk.

Clinical evidence

Results

3g

Clinically effective dose

confirmed across multiple independent RCTs - the same dose used in every key glycine sleep study

+80%

Reported improved sleep quality

of participants reported improved subjective sleep quality on 3g glycine vs. placebo (Yamadera et al., 2007)

30min

Before bed

optimal timing window - taken 30 minutes before sleep for full thermogenic and neurological effect

4

Independent RCTs

confirming glycine's effect on sleep onset, slow-wave sleep depth and next-day alertness

*Based on Yamadera et al. (2007), Bannai et al. (2012), and Inagawa et al. (2006) - peer-reviewed RCTs on 3g glycine taken before sleep.

Trusted by the best

From everyday high performers to elite athletes, CEOs & award winning academics.

Deep Dive

How glycine actually induces sleep

How glycine actually induces sleep

The key to falling asleep fast is a drop in core body temperature. Glycine achieves this by activating NMDA receptors in the suprachiasmatic nucleus (your circadian clock), triggering peripheral vasodilation - blood flows to your hands and feet, and heat leaves your core.

This mirrors what your body does naturally during healthy sleep onset, just faster and more reliably. Kawai et al. (2015) isolated this exact pathway using SCN lesion models in a peer-reviewed study published in Neuropsychopharmacology.

The morning-after edge

The morning-after edge

Usually sleep supplements are judged on how quickly they knock you out. Glycine is different - the real benchmark is how you feel the next day.

Inagawa et al. (2006) specifically studied glycine under sleep restriction: participants who took 3g showed significantly less daytime sleepiness and better performance on cognitive tasks vs. placebo. This is the part of the glycine story most people miss - it is not just a sleep aid, it is a recovery compound.

What the RCTs actually show

What the RCTs actually show

The landmark study by Yamadera et al. (2007) gave 3g glycine or placebo to adults with sleep complaints. Glycine significantly improved polysomnographic sleep efficiency, reduced time to slow-wave sleep and improved subjective sleep quality ratings.

Bannai et al. (2012) replicated and extended this, showing the morning-after effects: reduced fatigue, improved memory performance and sharper daytime alertness. Published in Sleep and Biological Rhythms and the Journal of Pharmacological Sciences - not supplement brand studies.

FAQs

Questions answered.

When should I take Glycine?

30 minutes before bed. This gives the thermogenic mechanism time to lower your core body temperature before you are trying to sleep. Mix into water, herbal tea or any other evening drink - it dissolves easily and has a mild sweet taste.

Can I stack it with 8hours Sleep & Recovery?

Yes. Glycine and Sleep & Recovery work through complementary pathways. Glycine targets core body temperature and NMDA receptor signalling. Sleep & Recovery targets GABA modulation, cortisol, melatonin precursors and magnesium repletion. Together they cover the full spectrum of sleep architecture.

Is Glycine habit-forming or sedating?

No on both counts. Glycine does not bind to GABA receptors or act like a sedative - you will not feel drugged or groggy. It is a naturally occurring amino acid your body already makes. You can take it nightly long-term without dependency concerns and stop at any time without withdrawal.

How long until I notice results?

Most people notice something within the first 2-3 nights - particularly faster sleep onset and waking feeling less groggy. Sleep quality improvements (deeper sleep, better structure) build over 2+ weeks of consistent nightly use.

Why powder and not capsules?

Dose. You would need 4-6 capsules per serving to hit the clinical 3g dose. Powder lets you hit the exact effective dose simply and economically. It dissolves cleanly and has a naturally mild, slightly sweet flavour that enhances your evening drink.

What does it mix with?

Anything. Water, herbal tea, warm milk, camomile - glycine is heat-stable and mixes cleanly without clumping. It has a subtle sweet taste that complements rather than competes with other evening drinks.

Reviews Deep Dive

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Customer Reviews

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Our promise

Take Glycine every night for 90 days and if you don't notice the difference, we will give you your money back.

Every first order is covered by our 90-day money-back guarantee. Pause or cancel your membership at any time.